INDIGO Biosciences Launches PrRPR/GPR10 Reporter Assay for Metabolic, Neuroendocrine, and Cardiometabolic Research

INDIGO Biosciences launched its Human PrRPR/GPR10 Reporter Assay, a new cell-based solution to accelerate therapeutic discovery in metabolic, neuroendocrine, stress biology, and cardiometabolic research. Targeting appetite regulation, stress response, and autonomic function, this assay utilizes proprietary CryoMite™ technology, enabling researchers to quickly obtain reliable data in as little as 24 hours. It's available as kits and through outsourcing services, simplifying complex workflows for drug discovery.

INDIGO Biosciences has announced the launch of its Human PrRPR/GPR10 Reporter Assay, an innovative cell-based solution designed to accelerate therapeutic discovery across metabolic, neuroendocrine, stress biology, and cardiometabolic research fields. This robust, ready-to-use platform allows scientists to effectively study the signaling of the Prolactin-Releasing Peptide Receptor (PrRPR), also known as GPR10.PrRPR is a critical class A G protein-coupled receptor found in hypothalamic and brainstem regions. Its activation by prolactin-releasing peptide (PrRP) impacts vital functions such as appetite regulation, stress response, metabolic homeostasis, and autonomic cardiovascular control. This positions PrRPR as a significant target for developing new therapies for conditions like obesity, stress-related disorders, and neuro-cardiometabolic diseases.Dr. Andrew Woodman, Lab Director at INDIGO Biosciences, emphasized that the new assay empowers researchers to gain a deeper understanding of receptor pharmacology and generate high-quality, reproducible data essential for emerging therapeutic strategies. A standout feature of the assay is INDIGO's proprietary CryoMite™ cryo-preservation process. This technology streamlines workflows by eliminating extensive cell culture preparation, allowing researchers to dispense healthy, division-competent cells immediately and obtain results in as little as 24 hours. The assay kit is comprehensive, including all necessary materials like optimized reporter cells, media, a validated reference agonist, and detection reagents, available in 96-well and 3x32-well formats, with options for high-throughput screening. Researchers can also opt for INDIGO’s assay outsourcing services for convenient and cost-effective testing.